Originated in 1925 by Raymond S. Mowery, the company began as a local residential and commercial construction company in Carlisle, Pennsylvania. Mowery's ability to consistently deliver quality work quickly earned the organization a reputation for reliability, and by the late 1940s, Mowery was constructing large commercial projects throughout the state. In 1953, the company incorporated as R. S. Mowery & Sons, Inc. Donald V. Mowery, son of Raymond, was named president in 1963 and retired in 1989. His son, Donald H. Mowery, became president in 1984.

Today, Mowery offers construction management, general construction, and design/build services for major institutional, industrial, and commercial clients. Construction management - in which Mowery works in conjunction with a project architect - constitutes 40 percent of the company business. Design/build - in which Mowery has complete responsibility for a building from start to finish - and general construction comprise the remaining 60 percent. Specialties include industrial and distribution facilities, buildings for colleges and universities, senior care communities, office complexes, and medical facilities.